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Issue 23, 2014
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Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform

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Abstract

We present a low-cost, portable microfluidic platform that uses laminated polymethylmethacrylate chips, peristaltic micropumps and LEGO® Mindstorms components for the generation of magnetoliposomes that does not require extrusion steps. Mixtures of lipids reconstituted in ethanol and an aqueous phase were injected independently in order to generate a combination of laminar flows in such a way that we could effectively achieve four hydrodynamic focused nanovesicle generation streams. Monodisperse magnetoliposomes with characteristics comparable to those obtained by traditional methods have been obtained. The magnetoliposomes are responsive to external magnetic field gradients, a result that suggests that the nanovesicles can be used in research and applications in nanomedicine.

Graphical abstract: Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform

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Article information


Submitted
17 Jul 2014
Accepted
11 Sep 2014
First published
11 Sep 2014

Lab Chip, 2014,14, 4506-4512
Article type
Paper
Author version available

Continuous flow generation of magnetoliposomes in a low-cost portable microfluidic platform

A. J. Conde, M. Batalla, B. Cerda, O. Mykhaylyk, C. Plank, O. Podhajcer, J. M. Cabaleiro, R. E. Madrid and L. Policastro, Lab Chip, 2014, 14, 4506
DOI: 10.1039/C4LC00839A

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