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Issue 18, 2014
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Cell detachment and label-free cell sorting using modulated surface acoustic waves (SAWs) in droplet-based microfluidics

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Abstract

We present a droplet-based surface acoustic wave (SAW) system designed to viably detach biological cells from a surface and sort cell types based on differences in adhesion strength (adhesion contrast) without the need to label cells with molecular markers. The system uses modulated SAW to generate pulsatile flows in the droplets and efficiently detach the cells, thereby minimizing the SAW excitation power and exposure time. As a proof of principle, the system shows efficient sorting of HEK 293 from A7r5 cells based on adhesion contrast. Results are obtained in minutes with sorting purity and efficiency reaching 97% and 95%, respectively.

Graphical abstract: Cell detachment and label-free cell sorting using modulated surface acoustic waves (SAWs) in droplet-based microfluidics

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Publication details

The article was received on 28 May 2014, accepted on 30 Jun 2014 and first published on 02 Jul 2014


Article type: Paper
DOI: 10.1039/C4LC00625A
Lab Chip, 2014,14, 3556-3563

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    Cell detachment and label-free cell sorting using modulated surface acoustic waves (SAWs) in droplet-based microfluidics

    A. Bussonnière, Y. Miron, M. Baudoin, O. Bou Matar, M. Grandbois, P. Charette and A. Renaudin, Lab Chip, 2014, 14, 3556
    DOI: 10.1039/C4LC00625A

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