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Issue 17, 2014
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Acoustic radiation forces at liquid interfaces impact the performance of acoustophoresis

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Abstract

Acoustophoresis is a method well suited for cell and microbead separation or concentration for downstream analysis in microfluidic settings. One of the main limitations that acoustophoresis share with other microfluidic techniques is that the separation efficiency is poor for particle-rich suspensions. We report that flow laminated liquids can be relocated in a microchannel when exposed to a resonant acoustic field. Differences in acoustic impedance between two liquids cause migration of the high-impedance liquid towards an acoustic pressure node. In a set of experiments we charted this phenomenon and show herein that it can be used to either relocate liquids with respect to each other, or to stabilize the interface between them. This resulted in decreased medium carry-over when transferring microbeads (4% by volume) between suspending liquids using acoustophoresis. Furthermore we demonstrate that acoustic relocation of liquids occurs for impedance differences as low as 0.1%.

Graphical abstract: Acoustic radiation forces at liquid interfaces impact the performance of acoustophoresis

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Publication details

The article was received on 15 May 2014, accepted on 25 Jun 2014 and first published on 26 Jun 2014


Article type: Paper
DOI: 10.1039/C4LC00572D
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Lab Chip, 2014,14, 3394-3400
  • Open access: Creative Commons BY-NC license
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    Acoustic radiation forces at liquid interfaces impact the performance of acoustophoresis

    S. Deshmukh, Z. Brzozka, T. Laurell and P. Augustsson, Lab Chip, 2014, 14, 3394
    DOI: 10.1039/C4LC00572D

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