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Issue 9, 2014
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Chitosan: an efficient recyclable catalyst for transamidation of carboxamides with amines under neat conditions

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Abstract

A novel chitosan-catalyzed transamidation of carboxamides with amines under solvent-free conditions is described. A series of amide derivatives as well as more challenging aryl and alkyl amines with long-chain alkyl substituents could be selectively converted into the corresponding transamidation products, which are frequently found in biologically active compounds and pharmaceuticals. Under similar reaction conditions benzo[d]heterocycles were also obtained via a one-pot synthesis through transamidation and subsequent dehydration. Recyclability of chitosan was demonstrated, with quantitative yields of products obtained without any loss of catalytic activity.

Graphical abstract: Chitosan: an efficient recyclable catalyst for transamidation of carboxamides with amines under neat conditions

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Publication details

The article was received on 23 Jul 2014, accepted on 25 Jul 2014 and first published on 28 Jul 2014


Article type: Communication
DOI: 10.1039/C4GC01402B
Green Chem., 2014,16, 4122-4126

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    Chitosan: an efficient recyclable catalyst for transamidation of carboxamides with amines under neat conditions

    S. Nageswara Rao, D. Chandra Mohan and S. Adimurthy, Green Chem., 2014, 16, 4122
    DOI: 10.1039/C4GC01402B

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