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Issue 3, 2014
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Efficient biocatalytic processes for highly valuable terminally phosphorylated C5 to C9 D-ketoses

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Abstract

A green enzymatic strategy for the synthesis of terminally phosphorylated C5 to C9 naturally occurring D-ketose phosphates and analogues was developed using D-fructose-6-phosphate aldolase (FSA) as a catalyst. This enzyme has stereoselectively catalysed aldol reactions between glycolaldehyde phosphate or ribose-5-phosphate as an acceptor substrate and dihydroxyacetone, hydroxyacetone or hydroxybutanone as a donor. Furthermore, D-glycero-D-altro-2-octulose 8-phosphate was obtained using a straightforward one-pot domino biocatalytic system involving FSA, ribulose-5-phosphate epimerase and ribose-5-phosphate isomerase controlling five contiguous asymmetric centres and starting from achiral material.

Graphical abstract: Efficient biocatalytic processes for highly valuable terminally phosphorylated C5 to C9 d-ketoses

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Publication details

The article was received on 16 Oct 2013, accepted on 26 Nov 2013 and first published on 26 Nov 2013


Article type: Communication
DOI: 10.1039/C3GC42140F
Citation: Green Chem., 2014,16, 1109-1113

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    Efficient biocatalytic processes for highly valuable terminally phosphorylated C5 to C9 D-ketoses

    C. Guérard-Hélaine, M. Debacker, P. Clapés, A. Szekrenyi, V. Hélaine and M. Lemaire, Green Chem., 2014, 16, 1109
    DOI: 10.1039/C3GC42140F

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