Issue 3, 2014
From the journal:

Green Chemistry

Trifluoromethylation of heterocycles in water at room temperature†

James C. Fennewalda  and  Bruce H. Lipshutz*a  

* Corresponding authors

a Department of Chemistry & Biochemistry, University of California, Santa Barbara 93106, USA
E-mail: lipshutz@chem.ucsb.edu

Abstract

Using a reaction medium containing nanoparticles consisting of commercially available TPGS-750-M in water, a combination of Langlois’ reagent and t-BuOOH can be used to effect trifluoromethylation of several heterocyclic arrays, including heteroaromatics. These reactions take place at ambient temperatures, and the aqueous medium can be recycled.

Graphical abstract: Trifluoromethylation of heterocycles in water at room temperature

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Article information

DOI
https://doi.org/10.1039/C3GC42119H
Article type
Communication
Submitted
11 Oct 2013
Accepted
20 Nov 2013
First published
05 Dec 2013

Green Chem., 2014,16, 1097-1100

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Trifluoromethylation of heterocycles in water at room temperature

J. C. Fennewald and B. H. Lipshutz, Green Chem., 2014, 16, 1097 DOI: 10.1039/C3GC42119H

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