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Issue 6, 2014
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Effects of raspberry fruit extracts and ellagic acid on respiratory burst in murine macrophages

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Abstract

The mechanism of action of polyphenolic compounds is attributed to their antioxidant, anti-inflammatory, and anti-proliferative properties and their effects on subcellular signal transduction, cell cycle impairment and apoptosis. A raspberry (Rubus idaeus L.) fruit extract contains various antioxidant active compounds, particularly ellagic acid (EA); however the exact intracellular mechanism of their action is not fully understood. The aim of the study was to evaluate the antioxidant effect of raspberry extracts, and that of ellagic acid by assessment of the production of the reactive oxygen species (ROS) by murine macrophage J774 cells. Raspberry extracts and their active compound EA did not affect or had very minor effects on cell viability. No significant difference in the ROS generation in arachidonic acid stimulated macrophages was determined for raspberry extracts and EA whereas in the phorbol-12 myristate-13 acetate model ROS generation was significantly (p < 0.05) reduced. Our observation that raspberry pomace extracts in vitro reduce ROS production in a J774 macrophage culture suggests that raspberry extract and ellagic acid mediated antioxidant effects may be due to the regulation of NADPH oxidase activity.

Graphical abstract: Effects of raspberry fruit extracts and ellagic acid on respiratory burst in murine macrophages

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Article information


Submitted
15 Nov 2013
Accepted
26 Feb 2014
First published
27 Feb 2014

Food Funct., 2014,5, 1167-1174
Article type
Paper
Author version available

Effects of raspberry fruit extracts and ellagic acid on respiratory burst in murine macrophages

L. Raudone, R. Bobinaite, V. Janulis, P. Viskelis and S. Trumbeckaite, Food Funct., 2014, 5, 1167
DOI: 10.1039/C3FO60593K

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