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Volume 175, 2014
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Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

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Abstract

We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] (1 and 2) in Pluronic® triblock copolymer P123 core–shell micelles. The spherical nanoparticles RuMs and OsMs, dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes 1 and 2 were highly active towards A2780 human ovarian cancer cells (IC50 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as RuMs and OsMs nanoparticles, were less potent (IC50 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells.

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Publication details

The article was received on 07 May 2014, accepted on 16 Jun 2014 and first published on 01 Oct 2014


Article type: Paper
DOI: 10.1039/C4FD00098F
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Citation: Faraday Discuss., 2014,175, 229-240
  • Open access: Creative Commons BY license
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    Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity

    N. P. E. Barry, A. Pitto-Barry, I. Romero-Canelón, J. Tran, J. J. Soldevila-Barreda, I. Hands-Portman, C. J. Smith, N. Kirby, A. P. Dove, R. K. O'Reilly and P. J. Sadler, Faraday Discuss., 2014, 175, 229
    DOI: 10.1039/C4FD00098F

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