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Issue 10, 2014
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Peptidomimetics via modifications of amino acids and peptide bonds

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Abstract

Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, sheets and loops can be accessed by chemical modifications of amino acids or peptides. In-depth structural and conformational analysis and structure–activity relationships (SAR) offer a way to establish peptidomimetic libraries. Herein, we review recent developments in peptidomimetics that are formed via heteroatom replacement within the native amino acid backbone. Each sub-section describes structural features, utility and preparative methods.

Graphical abstract: Peptidomimetics via modifications of amino acids and peptide bonds

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Publication details

The article was received on 28 Oct 2013 and first published on 13 Mar 2014


Article type: Review Article
DOI: 10.1039/C3CS60384A
Chem. Soc. Rev., 2014,43, 3575-3594

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    Peptidomimetics via modifications of amino acids and peptide bonds

    I. Avan, C. D. Hall and A. R. Katritzky, Chem. Soc. Rev., 2014, 43, 3575
    DOI: 10.1039/C3CS60384A

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