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Issue 21, 2014
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Magnetic nanoparticle clusters as actuators of ssDNA release

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Abstract

One of the major areas of research in nanomedicine is the design of drug delivery systems with remotely controllable release of the drug. Despite the enormous progress in the field, this aspect still poses a challenge, especially in terms of selectivity and possible harmful interactions with biological components other than the target. We report an innovative approach for the controlled release of DNA, based on clusters of core–shell magnetic nanoparticles. The primary nanoparticles are functionalized with a single-stranded oligonucleotide, whose pairing with a half-complementary strand in solution induces clusterization. The application of a low frequency (6 KHz) alternating magnetic field induces DNA melting with the release of the single strand that induces clusterization. The possibility of steering and localizing the magnetic nanoparticles, and magnetically actuating the DNA release discloses new perspectives in the field of nucleic-acid based therapy.

Graphical abstract: Magnetic nanoparticle clusters as actuators of ssDNA release

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Publication details

The article was received on 27 Dec 2013, accepted on 21 Jan 2014 and first published on 21 Jan 2014


Article type: Paper
DOI: 10.1039/C3CP55470H
Citation: Phys. Chem. Chem. Phys., 2014,16, 10023-10031
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    Magnetic nanoparticle clusters as actuators of ssDNA release

    M. Banchelli, S. Nappini, C. Montis, M. Bonini, P. Canton, D. Berti and P. Baglioni, Phys. Chem. Chem. Phys., 2014, 16, 10023
    DOI: 10.1039/C3CP55470H

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