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Issue 39, 2014
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Biomolecular structure manipulation using tailored electromagnetic radiation: a proof of concept on a simplified model of the active site of bacterial DNA topoisomerase

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Abstract

We report on the viability of breaking selected bonds in biological systems using tailored electromagnetic radiation. We first demonstrate, by performing large-scale simulations, that pulsed electric fields cannot produce selective bond breaking. Then, we present a theoretical framework for describing selective energy concentration on particular bonds of biomolecules upon application of tailored electromagnetic radiation. The theory is based on the mapping of biomolecules to a set of coupled harmonic oscillators and on optimal control schemes to describe optimization of temporal shape, the phase and polarization of the external radiation. We have applied this theory to demonstrate the possibility of selective bond breaking in the active site of bacterial DNA topoisomerase. For this purpose, we have focused on a model that was built based on a case study. Results are given as a proof of concept.

Graphical abstract: Biomolecular structure manipulation using tailored electromagnetic radiation: a proof of concept on a simplified model of the active site of bacterial DNA topoisomerase

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Article information


Submitted
24 May 2014
Accepted
26 Aug 2014
First published
08 Sep 2014

This article is Open Access

Phys. Chem. Chem. Phys., 2014,16, 21768-21777
Article type
Paper
Author version available

Biomolecular structure manipulation using tailored electromagnetic radiation: a proof of concept on a simplified model of the active site of bacterial DNA topoisomerase

D. Jarukanont, J. T. S. Coimbra, B. Bauerhenne, P. A. Fernandes, S. Patel, M. J. Ramos and M. E. Garcia, Phys. Chem. Chem. Phys., 2014, 16, 21768
DOI: 10.1039/C4CP02289K

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