Issue 9, 2014
From the journal:

Physical Chemistry Chemical Physics

An anticancer drug to probe non-specific protein–DNA interactions†

Abhigyan Sengupta,a   Raj Kumar Koninti,a   Krishna Gavvala,a   Nirmalya Ballava  and  Partha Hazra*a  

* Corresponding authors

a IISER-Pune, Maharashtra (411008), India
E-mail: p.hazra@iiserpune.ac.in
Fax: +91-20-2589 9790
Tel: +91-20-2590-8077

Abstract

A visible fluorescence switch of an eminent anti-carcinogen, ellipticine has been used to probe non-specific protein–DNA interaction. The unique pattern of protein–DNA complexation is depicted for the first time through field emission scanning electron microscopy (FE-SEM) images and spectroscopic techniques.

Graphical abstract: An anticancer drug to probe non-specific protein–DNA interactions

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Article information

DOI
https://doi.org/10.1039/C3CP54422B
Article type
Communication
Submitted
18 Oct 2013
Accepted
27 Nov 2013
First published
02 Dec 2013

Phys. Chem. Chem. Phys., 2014,16, 3914-3917

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An anticancer drug to probe non-specific protein–DNA interactions

A. Sengupta, R. K. Koninti, K. Gavvala, N. Ballav and P. Hazra, Phys. Chem. Chem. Phys., 2014, 16, 3914 DOI: 10.1039/C3CP54422B

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