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Issue 26, 2014
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Drug solid solutions – a method for tuning phase transformations

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Abstract

This paper describes a methodology for the modification of phase transition temperatures using (±)-4′-methylmethcathinone solid solutions as an exemplar. This method serves to show that by varying the composition of the halide ion one can systematically alter the temperatures at which phase transitions can occur in order to evade the possibility of interconversion between polymorphs during processing or storage of materials.

Graphical abstract: Drug solid solutions – a method for tuning phase transformations

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Article information


Submitted
27 Jan 2014
Accepted
25 Feb 2014
First published
03 Mar 2014

CrystEngComm, 2014,16, 5827-5831
Article type
Paper
Author version available

Drug solid solutions – a method for tuning phase transformations

A. Delori, P. Maclure, R. M. Bhardwaj, A. Johnston, A. J. Florence, O. B. Sutcliffe and I. D. H. Oswald, CrystEngComm, 2014, 16, 5827
DOI: 10.1039/C4CE00211C

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