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Issue 29, 2014
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Polymorphism of felodipine co-crystals with 4,4′-bipyridine

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Abstract

The calcium-channel blocking agent felodipine (Fel) forms co-crystals with 4,4′-bipyridine (BP) with 1 : 1 and 2 : 1 molar ratios. The [Fel + BP] (1 : 1) co-crystal exists in two polymorphic forms. Differential scanning calorimetry and solution calorimetry show that form I of the [Fel + BP] (1 : 1) co-crystal is the most thermodynamically stable phase. The difference in the crystal lattice energies between different polymorphs of the co-crystal is found to be comparable with that between the polymorphic forms of pure felodipine. The enthalpies of formation of the co-crystals are small, which indicates that the packing energy gain originates from only weak van der Waals interactions. Analysis of Hirshfeld surfaces of the felodipine molecule shows a similar distribution of intermolecular contacts in the co-crystals and pure felodipine.

Graphical abstract: Polymorphism of felodipine co-crystals with 4,4′-bipyridine

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Article information


Submitted
10 Apr 2014
Accepted
16 May 2014
First published
16 May 2014

CrystEngComm, 2014,16, 6603-6611
Article type
Paper
Author version available

Polymorphism of felodipine co-crystals with 4,4′-bipyridine

A. O. Surov, K. A. Solanko, A. D. Bond, A. Bauer-Brandl and G. L. Perlovich, CrystEngComm, 2014, 16, 6603
DOI: 10.1039/C4CE00756E

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