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Issue 32, 2014
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Drug–drug salt forms of ciprofloxacin with diflunisal and indoprofen

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Abstract

Two salt forms of a fluoroquinolone antibacterial drug, ciprofloxacin (CIP), with non-steroidal anti-inflammatory drugs, diflunisal (CIP/DIF) and indoprofen (CIP/INDP/H2O), were synthesized and characterized by PXRD, FTIR, DSC, TGA and HSM. Crystal structure determination allowed us to study the drug–drug interactions and the piperazine-based synthon (protonated piperazinecarboxylate) in the two forms, which is potentially useful for the crystal engineering of new salt forms of many piperazine-based drugs.

Graphical abstract: Drug–drug salt forms of ciprofloxacin with diflunisal and indoprofen

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Supplementary files

Article information


Submitted
27 Mar 2014
Accepted
12 Jun 2014
First published
13 Jun 2014

This article is Open Access

CrystEngComm, 2014,16, 7393-7396
Article type
Communication
Author version available

Drug–drug salt forms of ciprofloxacin with diflunisal and indoprofen

P. P. Bag, S. Ghosh, H. Khan, R. Devarapalli and C. Malla Reddy, CrystEngComm, 2014, 16, 7393
DOI: 10.1039/C4CE00631C

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