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Issue 22, 2014
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Synthon transferability probed with IR spectroscopy: cytosine salts as models for salts of lamivudine

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Abstract

Co-crystal screening of the anti-HIV drug lamivudine was carried out with dicarboxylic acids as co-formers, and three of the resulting crystalline solids, two salts and a co-crystal, were studied with SCXRD, PXRD and FTIR spectroscopy. Salts of cytosine, a molecule that incorporates critical structural features of lamivudine, with the same co-formers, were taken as model systems for IR spectroscopic studies of the synthons in the salts of lamivudine. It is shown that different systems with the same synthon show very similar spectral signatures in the regions corresponding to the synthon absorptions. This reveals again the modular nature of the supramolecular synthon.

Graphical abstract: Synthon transferability probed with IR spectroscopy: cytosine salts as models for salts of lamivudine

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Supplementary files

Article information


Submitted
24 Oct 2013
Accepted
26 Nov 2013
First published
12 Dec 2013

CrystEngComm, 2014,16, 4732-4741
Article type
Paper
Author version available

Synthon transferability probed with IR spectroscopy: cytosine salts as models for salts of lamivudine

S. Chakraborty, S. Ganguly and G. R. Desiraju, CrystEngComm, 2014, 16, 4732
DOI: 10.1039/C3CE42156B

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