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Issue 17, 2014
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Polymorphism in cocrystals: a review and assessment of its significance

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Abstract

Cocrystals have gained much interest in recent years owing to their potential to improve the physicochemical properties of the parent compounds. It was once thought that cocrystals could be a means to prevent polymorphism but many recent examples of cocrystal polymorphism have been discovered and reported. Similar to single component crystals, polymorphs of cocrystals can display significantly different properties. In this contribution, we present a survey of polymorphic cocrystals. The different types of polymorphs, namely synthon, conformational, packing, and tautomeric, are identified and discussed with representative examples. In addition, polymorphs of cocrystals that showed distinct physicochemical properties are highlighted.

Graphical abstract: Polymorphism in cocrystals: a review and assessment of its significance

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Publication details

The article was received on 04 Oct 2013, accepted on 11 Feb 2014 and first published on 12 Feb 2014


Article type: Highlight
DOI: 10.1039/C3CE42008F
CrystEngComm, 2014,16, 3451-3465

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    Polymorphism in cocrystals: a review and assessment of its significance

    S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2014, 16, 3451
    DOI: 10.1039/C3CE42008F

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