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Issue 75, 2014
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Gold nanoparticles decorated by clustered multivalent cone-glycocalixarenes actively improve the targeting efficiency toward cancer cells

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Abstract

A novel approach for multivalent targeting by using gold nanoparticles noncovalently decorated by tight functionalization with a cone-glycocalixarene bearing four mannose units is reported. The targeting efficiency of these multivalent nanoparticles is shown to be remarkably improved compared to that of nanoparticles bearing a monovalent mannosylated derivative.

Graphical abstract: Gold nanoparticles decorated by clustered multivalent cone-glycocalixarenes actively improve the targeting efficiency toward cancer cells

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Publication details

The article was received on 28 Apr 2014, accepted on 31 Jul 2014 and first published on 31 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC03159H
Citation: Chem. Commun., 2014,50, 11029-11032

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    Gold nanoparticles decorated by clustered multivalent cone-glycocalixarenes actively improve the targeting efficiency toward cancer cells

    S. Avvakumova, P. Fezzardi, L. Pandolfi, M. Colombo, F. Sansone, A. Casnati and D. Prosperi, Chem. Commun., 2014, 50, 11029
    DOI: 10.1039/C4CC03159H

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