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Issue 26, 2014
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Profiling of RNA modifications by multiplexed stable isotope labelling

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Abstract

The combination of 15N/13C stable isotope labelling (SIL) and LC-MS/MS revealed a total of 52 modifications in RNA from E. coli and yeast, including 10 previously undescribed modifications. Two modifications, N-ribosylnicotinamide and 2-methylthioadenosine, were newly detected in species hitherto thought not to contain these modifications.

Graphical abstract: Profiling of RNA modifications by multiplexed stable isotope labelling

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Supplementary files

Article information


Submitted
29 Nov 2013
Accepted
05 Feb 2014
First published
24 Feb 2014

Chem. Commun., 2014,50, 3516-3518
Article type
Communication

Profiling of RNA modifications by multiplexed stable isotope labelling

S. Kellner, J. Neumann, D. Rosenkranz, S. Lebedeva, R. F. Ketting, H. Zischler, D. Schneider and M. Helm, Chem. Commun., 2014, 50, 3516
DOI: 10.1039/C3CC49114E

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