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Issue 14, 2014
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Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

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Abstract

Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.

Graphical abstract: Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

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Supplementary files

Article information


Submitted
13 Nov 2013
Accepted
16 Dec 2013
First published
17 Dec 2013

Chem. Commun., 2014,50, 1688-1690
Article type
Communication
Author version available

Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

H. D. Williams, Y. Sahbaz, L. Ford, T. Nguyen, P. J. Scammells and C. J. H. Porter, Chem. Commun., 2014, 50, 1688
DOI: 10.1039/C3CC48650H

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