Issue 93, 2014
From the journal:

Chemical Communications

Amine-accelerated manganese-catalyzed aromatic C–H conjugate addition to α,β-unsaturated carbonyls†

Bingwei Zhou,a   Pengchen Ma,b   Hui Chen*b  and  Congyang Wang*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: wangcy@iccas.ac.cn
Web: http://wangcy.iccas.ac.cn/
Fax: +86 10 62554449
Tel: +86 10 82615073

b CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: chenh@iccas.ac.cn

Abstract

Since 1987, the stoichiometric two-step C–H conjugate addition reactions have been developed. Herein we describe the first manganese-catalyzed one-step direct aromatic C–H conjugate addition to α,β-unsaturated carbonyls, which is accelerated by a catalytic amount of dicyclohexylamine. Experimental and computational studies substantiated the validity of the proposed catalytic cycle.

Graphical abstract: Amine-accelerated manganese-catalyzed aromatic C–H conjugate addition to α,β-unsaturated carbonyls

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Article information

DOI
https://doi.org/10.1039/C4CC07598F
Article type
Communication
Submitted
26 Sep 2014
Accepted
06 Oct 2014
First published
06 Oct 2014

Chem. Commun., 2014,50, 14558-14561

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Amine-accelerated manganese-catalyzed aromatic C–H conjugate addition to α,β-unsaturated carbonyls

B. Zhou, P. Ma, H. Chen and C. Wang, Chem. Commun., 2014, 50, 14558 DOI: 10.1039/C4CC07598F

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