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Issue 100, 2014
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Toll-like receptor agonist lipopeptides self-assemble into distinct nanostructures

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Abstract

The self-assembled structure of toll-like receptor agonist lipopeptides containing the CSK4 peptide sequence is examined in aqueous solution. A remarkable dependence of morphology on the number of attached hexadecyl lipid chains is demonstrated, with spherical micelle structures for mono- and di-lipidated structures observed, but flexible wormlike micelles for the homologue containing three lipid chains. The distinct modes of assembly may have an important influence on the bioactivity of this class of lipopeptide.

Graphical abstract: Toll-like receptor agonist lipopeptides self-assemble into distinct nanostructures

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Supplementary files

Article information


Submitted
23 Sep 2014
Accepted
29 Oct 2014
First published
30 Oct 2014

This article is Open Access

Chem. Commun., 2014,50, 15948-15951
Article type
Communication
Author version available

Toll-like receptor agonist lipopeptides self-assemble into distinct nanostructures

I. W. Hamley, S. Kirkham, A. Dehsorkhi, V. Castelletto, M. Reza and J. Ruokolainen, Chem. Commun., 2014, 50, 15948
DOI: 10.1039/C4CC07511K

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