Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 100, 2014
Previous Article Next Article

Toll-like receptor agonist lipopeptides self-assemble into distinct nanostructures

Author affiliations

Abstract

The self-assembled structure of toll-like receptor agonist lipopeptides containing the CSK4 peptide sequence is examined in aqueous solution. A remarkable dependence of morphology on the number of attached hexadecyl lipid chains is demonstrated, with spherical micelle structures for mono- and di-lipidated structures observed, but flexible wormlike micelles for the homologue containing three lipid chains. The distinct modes of assembly may have an important influence on the bioactivity of this class of lipopeptide.

Graphical abstract: Toll-like receptor agonist lipopeptides self-assemble into distinct nanostructures

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Sep 2014, accepted on 29 Oct 2014 and first published on 30 Oct 2014


Article type: Communication
DOI: 10.1039/C4CC07511K
Author version
available:
Download author version (PDF)
Citation: Chem. Commun., 2014,50, 15948-15951
  • Open access: Creative Commons BY license
  •   Request permissions

    Toll-like receptor agonist lipopeptides self-assemble into distinct nanostructures

    I. W. Hamley, S. Kirkham, A. Dehsorkhi, V. Castelletto, M. Reza and J. Ruokolainen, Chem. Commun., 2014, 50, 15948
    DOI: 10.1039/C4CC07511K

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements