Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based ‘click’ ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.
A. R. O. Cousins, D. Ritson, P. Sharma, M. F. G. Stevens, J. E. Moses and M. S. Searle, Chem. Commun., 2014, 50, 15202 DOI: 10.1039/C4CC07487D
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