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Issue 95, 2014
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A disulfide polymerized protein crystal

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The vDED coiled coil domain from human BAP29 was crystallized in dimeric and tetrameric forms. For the dimer, a disulfide bond was unexpectedly found to bridge a crystal contact, resulting in complete cross-linking along the c-axis. This indicates that it is in principle possible to design spontaneously polymerizing protein crystals.

Graphical abstract: A disulfide polymerized protein crystal

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The article was received on 16 Sep 2014, accepted on 13 Oct 2014 and first published on 14 Oct 2014

Article type: Communication
DOI: 10.1039/C4CC07326F
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Citation: Chem. Commun., 2014,50, 14995-14997
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    A disulfide polymerized protein crystal

    E. M. Quistgaard, Chem. Commun., 2014, 50, 14995
    DOI: 10.1039/C4CC07326F

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