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Issue 92, 2014
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A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy

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Abstract

We report a dual functional aggregation-enhanced emission (AEE) molecule, TPE-IQ, which could target and illuminate mitochondria in both live and fixed cells with superb selectivity and high signal-to-noise ratio. More intriguingly, TPE-IQ can serve as a photosensitizer to generate reactive oxygen species (ROS) in the mitochondria region to induce cell apoptosis.

Graphical abstract: A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy

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Publication details

The article was received on 10 Sep 2014, accepted on 26 Sep 2014 and first published on 26 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC07128J
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Citation: Chem. Commun., 2014,50, 14451-14454

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    A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy

    E. Zhao, H. Deng, S. Chen, Y. Hong, C. W. T. Leung, J. W. Y. Lam and B. Z. Tang, Chem. Commun., 2014, 50, 14451
    DOI: 10.1039/C4CC07128J

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