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Issue 93, 2014
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An ESR and DFT study of hydration of the 2′-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate

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Abstract

The mechanism of radiation-induced frank strand break formation in irradiated 5-bromo-2′-deoxyuridine (BrdU)-labelled DNA is still unclear despite the proven radiosensitizing properties of BrdU. Combination of ESR spectroscopy and quantum chemical modelling points to a simple reaction between the uridine-5-yl radical and water molecules that produces the genotoxic hydroxyl radical.

Graphical abstract: An ESR and DFT study of hydration of the 2′-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate

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Article information


Submitted
08 Sep 2014
Accepted
01 Oct 2014
First published
01 Oct 2014

Chem. Commun., 2014,50, 14605-14608
Article type
Communication

An ESR and DFT study of hydration of the 2′-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate

L. Chomicz, A. Petrovici, I. Archbold, A. Adhikary, A. Kumar, M. D. Sevilla and J. Rak, Chem. Commun., 2014, 50, 14605
DOI: 10.1039/C4CC07089E

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