Oxidation-responsive Eu2+/3+-liposomal contrast agent for dual-mode magnetic resonance imaging

Levi A. Ekanger; Meser M. Ali; Matthew J. Allen

doi:10.1039/C4CC07027E

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Oxidation-responsive Eu^2+/3+-liposomal contrast agent for dual-mode magnetic resonance imaging†

Levi A. Ekanger,^a Meser M. Ali^b and Matthew J. Allen*^a

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* Corresponding authors

^a Department of Chemistry, Wayne State University, 5101 Cass Ave., Detroit, MI 48202, USA
E-mail: mallen@chem.wayne.edu

^b Department of Neurology, Henry Ford Hospital, 1 Ford Place, Detroit, MI 48202, USA

Abstract

An oxidation-responsive contrast agent for magnetic resonance imaging was synthesized using Eu²⁺ and liposomes. Positive contrast enhancement was observed with Eu²⁺, and chemical exchange saturation transfer was observed before and after oxidation of Eu²⁺. Orthogonal detection modes render the concentration of Eu inconsequential to molecular information provided through imaging.

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Article information

DOI: https://doi.org/10.1039/C4CC07027E
Article type: Communication
Submitted: 05 Sep 2014
Accepted: 10 Oct 2014
First published: 17 Oct 2014

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Chem. Commun., 2014,50, 14835-14838

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Oxidation-responsive Eu^2+/3+-liposomal contrast agent for dual-mode magnetic resonance imaging

L. A. Ekanger, M. M. Ali and M. J. Allen, Chem. Commun., 2014, 50, 14835 DOI: 10.1039/C4CC07027E

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Chemical Communications