Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: a facile strategy for the synthesis of 7-substituted indoles

Minyoung Kim; Neeraj Kumar Mishra; Jihye Park; Sangil Han; Youngmi Shin; Satyasheel Sharma; Youngil Lee; Eui-Kyung Lee; Jong Hwan Kwak; In Su Kim

doi:10.1039/C4CC06929C

Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: a facile strategy for the synthesis of 7-substituted indoles†

Minyoung Kim,^a Neeraj Kumar Mishra,^a Jihye Park,^a Sangil Han,^a Youngmi Shin,^a Satyasheel Sharma,^a Youngil Lee,^b Eui-Kyung Lee,^a Jong Hwan Kwak^a and In Su Kim*^a

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^a School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: insukim@skku.edu
Fax: +82 31 292 8800
Tel: +82 31 290 7788

^b Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea

Abstract

Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C–H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles.

Chemical Communications

Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: a facile strategy for the synthesis of 7-substituted indoles†

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Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: a facile strategy for the synthesis of 7-substituted indoles

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