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Issue 86, 2014
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Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes

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Abstract

A number of non-canonical amino acids (NCAAs) with unstrained olefins are genetically encoded using mutant pyrrolysyl-tRNA synthetase–tRNAPylCUA pairs. These NCAAs readily undergo inverse electron-demand Diels–Alder cycloadditions with tetrazine dyes, leading to selective labeling of proteins bearing these NCAAs in live cells.

Graphical abstract: Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes

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Publication details

The article was received on 15 Aug 2014, accepted on 02 Sep 2014 and first published on 03 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC06435F
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Citation: Chem. Commun., 2014,50, 13085-13088
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    Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes

    Y. Lee, Y. Kurra, Y. Yang, J. Torres-Kolbus, A. Deiters and W. R. Liu, Chem. Commun., 2014, 50, 13085
    DOI: 10.1039/C4CC06435F

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