Issue 99, 2014
From the journal:

Chemical Communications

Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease†

Yanli Tian,‡ab   Xueli Zhang,‡acd   Yuyan Li,ac   Timothy M. Shoup,e   Xin Teng,e   David R. Elmaleh,e   Anna Moore*a  and  Chongzhao Ran*a  

* Corresponding authors

a Molecular Imaging Laboratory, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Building 75, Charlestown, Massachusetts 02129, USA
E-mail: cran@nmr.mgh.harvard.edu, amoore@helix.mgh.harvard.edu

b Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China

c School of Pharmacy, China Pharmaceutical University, Nanjing, China

d Department of Pharmacy, ZhongDa Hospital, Southeast University, Nanjing, China

e Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA

Abstract

In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice.

Graphical abstract: Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease

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Article information

DOI
https://doi.org/10.1039/C4CC06029F
Article type
Communication
Submitted
02 Aug 2014
Accepted
28 Oct 2014
First published
28 Oct 2014

Chem. Commun., 2014,50, 15792-15795

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Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease

Y. Tian, X. Zhang, Y. Li, T. M. Shoup, X. Teng, D. R. Elmaleh, A. Moore and C. Ran, Chem. Commun., 2014, 50, 15792 DOI: 10.1039/C4CC06029F

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