An asymmetric cascade Mannich/cyclization reaction between 3-isothiocyanato oxindoles and sulfimides using a commercially available organocatalyst has been developed. A wide range of structurally diverse spiro[imidazolidine-4,3′-oxindole] derivatives were obtained with good yields (up to 92%) and excellent enantioselectivities (up to 99% ee).
H. Cai, Y. Zhou, D. Zhang, J. Xu and H. Liu, Chem. Commun., 2014, 50, 14771 DOI: 10.1039/C4CC06000H
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