Issue 96, 2014
From the journal:

Chemical Communications

Diastereoselective synthesis of α-(aminomethyl)-γ-butyrolactones via a catalyst-free aminolactonization†

P. Veeraraghavan Ramachandran*a  and  Daniel R. Nicponskia  

* Corresponding authors

a Department of Chemistry, Purdue University, West Lafayette, IN, 47907-2084 USA
E-mail: chandran@purdue.edu

Abstract

An auto-catalytic domino reaction, presumably involving an aza-Michael reaction, proton transfer, and lactonization, furnishing α-(aminomethyl)-γ-butyrolactones in near quantitative yields and excellent diastereoselectivity is described.

Graphical abstract: Diastereoselective synthesis of α-(aminomethyl)-γ-butyrolactones via a catalyst-free aminolactonization

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Article information

DOI
https://doi.org/10.1039/C4CC05765A
Article type
Communication
Submitted
24 Jul 2014
Accepted
09 Oct 2014
First published
09 Oct 2014

Chem. Commun., 2014,50, 15216-15219

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Diastereoselective synthesis of α-(aminomethyl)-γ-butyrolactones via a catalyst-free aminolactonization

P. V. Ramachandran and D. R. Nicponski, Chem. Commun., 2014, 50, 15216 DOI: 10.1039/C4CC05765A

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