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Issue 78, 2014
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A multimeric MR-optical contrast agent for multimodal imaging

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Abstract

We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.

Graphical abstract: A multimeric MR-optical contrast agent for multimodal imaging

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Publication details

The article was received on 21 Jul 2014, accepted on 14 Aug 2014 and first published on 14 Aug 2014


Article type: Communication
DOI: 10.1039/C4CC05651E
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Chem. Commun., 2014,50, 11469-11471

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    A multimeric MR-optical contrast agent for multimodal imaging

    V. S. R. Harrison, C. E. Carney, K. W. Macrenaris and T. J. Meade, Chem. Commun., 2014, 50, 11469
    DOI: 10.1039/C4CC05651E

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