Issue 97, 2014
From the journal:

Chemical Communications

Synergistic dual-targeting hydrogel improves targeting and anticancer effect of Taxol in vitro and in vivo†

Chang Shu,a   Ruixin Li,a   Yajun Yin,a   Deyan Yin,b   Yueqing Gu,b   Li Ding*c  and  Wenying Zhong*a  

* Corresponding authors

a Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, P. R. China
E-mail: wyzhong@cpu.edu.cn

b Department of Biomedical Engineering, China Pharmaceutical University, Nanjing, P. R. China

c Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, P. R. China
E-mail: dinglihg@sina.com

Abstract

A synergistic dual-targeting molecular self-assembly hydrogel was designed with estrone (Et) and Arg–Gly–Asp (RGD) peptide. Confocal imaging in vitro and real-time visualization in vivo researches were carried out to evidence enhanced targeted delivery and anticancer effect of Taxol.

Graphical abstract: Synergistic dual-targeting hydrogel improves targeting and anticancer effect of Taxol in vitro and in vivo

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Article information

DOI
https://doi.org/10.1039/C4CC05614K
Article type
Communication
Submitted
21 Jul 2014
Accepted
14 Oct 2014
First published
14 Oct 2014

Chem. Commun., 2014,50, 15423-15426

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Synergistic dual-targeting hydrogel improves targeting and anticancer effect of Taxol in vitro and in vivo

C. Shu, R. Li, Y. Yin, D. Yin, Y. Gu, L. Ding and W. Zhong, Chem. Commun., 2014, 50, 15423 DOI: 10.1039/C4CC05614K

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