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Issue 82, 2014
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H2Me-do2pa: an attractive chelator with fast, stable and inert natBi3+ and 213Bi3+ complexation for potential α-radioimmunotherapy applications

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Abstract

The complexation properties of H2Me-do2pa towards natBi3+ reveal a rather fast formation of the [Bi(Me-do2pa)]+ complex, which is endowed with a very high thermodynamic stability (log KBiL = 34.2) and presents a single non-fluxional structure in solution. X-ray diffraction and solution NMR studies showed an octadentate binding of the ligand to the metal ion. The labelling of H2Me-do2pa with 213Bi was performed and the resulting complex was stable in vitro, sustaining its use as an attractive alternative to H4dota taken here as a reference.

Graphical abstract: H2Me-do2pa: an attractive chelator with fast, stable and inert natBi3+ and 213Bi3+ complexation for potential α-radioimmunotherapy applications

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Publication details

The article was received on 17 Jul 2014, accepted on 25 Aug 2014 and first published on 25 Aug 2014


Article type: Communication
DOI: 10.1039/C4CC05529B
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Chem. Commun., 2014,50, 12371-12374

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    H2Me-do2pa: an attractive chelator with fast, stable and inert natBi3+ and 213Bi3+ complexation for potential α-radioimmunotherapy applications

    L. M. P. Lima, M. Beyler, F. Oukhatar, P. Le Saec, A. Faivre-Chauvet, C. Platas-Iglesias, R. Delgado and R. Tripier, Chem. Commun., 2014, 50, 12371
    DOI: 10.1039/C4CC05529B

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