Issue 80, 2014
From the journal:

Chemical Communications

A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy†

Shi-Ying Li,‡a   Li-Han Liu,‡a   Hui-Zhen Jia,a   Wen-Xiu Qiu,a   Lei Rong,a   Hong Chenga  and  Xian-Zheng Zhang*a  

* Corresponding authors

a Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
E-mail: xz-zhang@whu.edu.cn
Fax: +86 27 6875 4509
Tel: +86 27 6875 5993

Abstract

A novel cancer targeting and pH-responsive prodrug was successfully designed and synthesized. This M-prodrug was demonstrated to have real-time drug release monitoring capability based on the concept of contact-mediated quenching between doxorubicin and a coumarin derivative.

Graphical abstract: A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy

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Article information

DOI
https://doi.org/10.1039/C4CC05008H
Article type
Communication
Submitted
01 Jul 2014
Accepted
13 Aug 2014
First published
13 Aug 2014

Chem. Commun., 2014,50, 11852-11855

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A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy

S. Li, L. Liu, H. Jia, W. Qiu, L. Rong, H. Cheng and X. Zhang, Chem. Commun., 2014, 50, 11852 DOI: 10.1039/C4CC05008H

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