Issue 97, 2014
From the journal:

Chemical Communications

A mitochondria-targeted protonophoric uncoupler derived from fluorescein†

Stepan S. Denisov,ab   Elena A. Kotova,a   Egor Y. Plotnikov,a   Artur A. Tikhonov,b   Dmitry B. Zorov,a   Galina A. Korshunovaa  and  Yuri N. Antonenko*a  

* Corresponding authors

a Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1, Moscow 119991, Russia
E-mail: antonen@genebee.msu.ru

b Faculty of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia

Abstract

Linking decyl-triphenyl-phosphonium to fluorescein yields a fluorescent probe that accumulates in energized mitochondria, facilitates proton transfer across membranes and stimulates mitochondrial respiration. This features a mitochondria-targeted uncoupler, being of potential interest for therapeutic use against oxidative stress-related diseases.

Graphical abstract: A mitochondria-targeted protonophoric uncoupler derived from fluorescein

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Article information

DOI
https://doi.org/10.1039/C4CC04996A
Article type
Communication
Submitted
03 Jul 2014
Accepted
16 Oct 2014
First published
16 Oct 2014

Chem. Commun., 2014,50, 15366-15369

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A mitochondria-targeted protonophoric uncoupler derived from fluorescein

S. S. Denisov, E. A. Kotova, E. Y. Plotnikov, A. A. Tikhonov, D. B. Zorov, G. A. Korshunova and Y. N. Antonenko, Chem. Commun., 2014, 50, 15366 DOI: 10.1039/C4CC04996A

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