Issue 72, 2014
From the journal:

Chemical Communications

Directly utilizing an endogenous gene to dissect regulatory elements in the biosynthetic gene cluster of nosiheptide†

Min Ma,a   Yanjiu Xue,a   Weiying Liu,a   Hong Zhang,a   Lingyi Kong,a   Shuzhen Wang*a  and  Yijun Chen*a  

* Corresponding authors

a State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, China
E-mail: yjchen@cpu.edu.cn, shuzhenwang@cpu.edu.cn
Fax: +86 25 83271031
Tel: +86 25 83271045

Abstract

The regulatory elements for nosiheptide biosynthesis were identified by a novel host–vector system with an endogenous gene within the biosynthetic gene cluster as a reporter gene. The present study offers a rapid and reliable method for the identification of regulatory elements in the biosynthesis of various bioactive natural products.

Graphical abstract: Directly utilizing an endogenous gene to dissect regulatory elements in the biosynthetic gene cluster of nosiheptide

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Article information

DOI
https://doi.org/10.1039/C4CC04974H
Article type
Communication
Submitted
30 Jun 2014
Accepted
18 Jul 2014
First published
18 Jul 2014

Chem. Commun., 2014,50, 10430-10433

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Directly utilizing an endogenous gene to dissect regulatory elements in the biosynthetic gene cluster of nosiheptide

M. Ma, Y. Xue, W. Liu, H. Zhang, L. Kong, S. Wang and Y. Chen, Chem. Commun., 2014, 50, 10430 DOI: 10.1039/C4CC04974H

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