A new protocol has been developed for trifluoromethylation of arenediazonium salts with moisture-sensitive CuCF3 (from fluoroform) in aqueous media. The reaction is governed by a radical mechanism, tolerates a broad variety of functional groups, and is applicable to the synthesis of complex, polyfunctionalized molecules.
A. Lishchynskyi, G. Berthon and V. V. Grushin, Chem. Commun., 2014, 50, 10237 DOI: 10.1039/C4CC04930F
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