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Issue 72, 2014
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Protein assembly mediated by sulfonatocalix[4]arene

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A crystal structure of lysozyme in complex with p-sulfonato-calix[4]arene (sclx4) reveals a linear assembly of protein tetramers glued together by protein–calixarene interactions. One interaction involves encapsulation of the highly exposed C-terminal Arg128. The other involves an intricate protein-bound complex of sclx4, Mg2+ and a fragment of polyethylene glycol.

Graphical abstract: Protein assembly mediated by sulfonatocalix[4]arene

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The article was received on 26 Jun 2014, accepted on 21 Jul 2014 and first published on 21 Jul 2014

Article type: Communication
DOI: 10.1039/C4CC04897K
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Citation: Chem. Commun., 2014,50, 10412-10415
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    Protein assembly mediated by sulfonatocalix[4]arene

    R. E. McGovern, A. A. McCarthy and P. B. Crowley, Chem. Commun., 2014, 50, 10412
    DOI: 10.1039/C4CC04897K

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