Issue 87, 2014

On the interaction of copper(ii) with disulfiram


In combination with copper(II) ions, disulfiram (DSF) has been reported to be a potentially potent anticancer agent based on in vitro results. The interaction of DSF with copper(II) chloride in solution has been studied using a range of spectroscopic techniques. There is strong evidence for the rapid formation of the bis(N,N-diethyl dithiocarbamato)copper(II) complex in situ. Kinetic experiments were used to determine rate laws for the reaction that give insight into the mechanism of the process which may help to explain the observed in vitro cytotoxicity.

Graphical abstract: On the interaction of copper(ii) with disulfiram

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Article information

Article type
23 Jun 2014
11 Sep 2014
First published
11 Sep 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 13334-13337

Author version available

On the interaction of copper(II) with disulfiram

D. J. Lewis, P. Deshmukh, A. A. Tedstone, F. Tuna and P. O'Brien, Chem. Commun., 2014, 50, 13334 DOI: 10.1039/C4CC04767B

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