Transmission electron microscopy enables the reconstruction of the catenane and ring forms of CS2 hydrolase

Joseph Che-Yen Wang; Adam Zlotnick; Jasmin Mecinović

doi:10.1039/C4CC04650A

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Transmission electron microscopy enables the reconstruction of the catenane and ring forms of CS₂ hydrolase†

Joseph Che-Yen Wang,*^a Adam Zlotnick^a and Jasmin Mecinović*^b

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* Corresponding authors

^a Molecular & Cellular Biochemistry Department, Simon Hall 217, 212 S. Hawthorne Drive, Indiana University, Bloomington, IN 47405, USA
E-mail: wangjoe@indiana.edu
Fax: +1 812 856 5710
Tel: +1 812 856 1874

^b Institute for Molecules and Materials, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
E-mail: j.mecinovic@science.ru.nl
Fax: +31 24 3653393
Tel: +31 24 3652381

Abstract

Transmission electron microscopic studies on CS₂ hydrolase provide direct evidence for the existence of the hexadecameric catenane and octameric ring topologies. Reconstructions of both protein assemblies are in good agreement with crystallographic analyses of the catenane and ring forms of CS₂ hydrolase.

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Article information

DOI: https://doi.org/10.1039/C4CC04650A
Article type: Communication
Submitted: 19 Jun 2014
Accepted: 18 Jul 2014
First published: 18 Jul 2014

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Chem. Commun., 2014,50, 10281-10283

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Transmission electron microscopy enables the reconstruction of the catenane and ring forms of CS₂ hydrolase

J. C. Wang, A. Zlotnick and J. Mecinović, Chem. Commun., 2014, 50, 10281 DOI: 10.1039/C4CC04650A

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