Issue 96, 2014

Phase-transition contrast nanocapsules triggered by low-intensity ultrasound

Abstract

A polymeric nanocapsule encapsulated with 1,1,1,3,3-pentafluorobutane was developed, in which 2,2,3,3,4,4,4-heptafluoro-1-butyl groups were introduced to the polymer terminal for high loading of liquid fluorocarbon. In vitro experiments demonstrate that its liquid/gas-phase transition can be triggered by mild heating. This nanocapsule can be harnessed as a contrast agent for tumor imaging under diagnostic ultrasound.

Graphical abstract: Phase-transition contrast nanocapsules triggered by low-intensity ultrasound

Supplementary files

Article information

Article type
Communication
Submitted
22 Jun 2014
Accepted
06 Oct 2014
First published
06 Oct 2014

Chem. Commun., 2014,50, 15163-15166

Author version available

Phase-transition contrast nanocapsules triggered by low-intensity ultrasound

H. Li, J. Wang, P. Wang, J. Zheng, F. Song, T. Yin, G. Zhou, R. Zheng and C. Zhang, Chem. Commun., 2014, 50, 15163 DOI: 10.1039/C4CC04641B

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