Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan

Abdul Hakeem; Ruixue Duan; Fouzia Zahid; Chao Dong; Boya Wang; Fan Hong; Xiaowen Ou; Yongmei Jia; Xiaoding Lou; Fan Xia

doi:10.1039/C4CC04383A

Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan†

Abdul Hakeem,^a Ruixue Duan,^a Fouzia Zahid,^a Chao Dong,^a Boya Wang,^a Fan Hong,^a Xiaowen Ou,^a Yongmei Jia,^a Xiaoding Lou*^a and Fan Xia*^a

Author affiliations

* Corresponding authors

^a Key Laboratory for Large-Format Battery Materials and Systems, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
E-mail: louxiaoding@hust.edu.cn, xiafan@hust.edu.cn

Abstract

Herein, we report natural chitosan end-capped MCM-41 type MSNPs as novel, dual stimuli, responsive nano-vehicles for controlled anticancer drug delivery. The chitosan nanovalves tightly close the pores of the MSNPs to control premature cargo release under physiological conditions but respond to lysozyme and acidic media to release the trapped cargo.

Chemical Communications

Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan

Social activity

Search articles by author

Spotlight

Advertisements