Simultaneous 1H and 13C NMR enantiodifferentiation from highly-resolved pure shift HSQC spectra

Míriam Pérez-Trujillo; Laura Castañar; Eva Monteagudo; Lars T. Kuhn; Pau Nolis; Albert Virgili; R. Thomas Williamson; Teodor Parella

doi:10.1039/C4CC04077E

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Simultaneous ¹H and ¹³C NMR enantiodifferentiation from highly-resolved pure shift HSQC spectra†

Míriam Pérez-Trujillo,^a Laura Castañar,^a Eva Monteagudo,^a Lars T. Kuhn,^b Pau Nolis,^a Albert Virgili,^a R. Thomas Williamson^c and Teodor Parella*^a

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* Corresponding authors

^a Servei de Ressonància Magnètica Nuclear and Departament de Química, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Barcelona, Spain
E-mail: teodor.parella@uab.cat
Tel: +34 935812291

^b DFG Research Center Molecular Physiology of the Brain (CMPB) & European Neuroscience Institute Göttingen (ENI-G), Göttingen, Germany

^c NMR Structure Elucidation, Process and Analytical Chemistry, Merck & Co. Inc., 126 E. Lincoln Avenue, Rahway, USA

Abstract

NMR enantiodifferentiation studies are greatly improved by the simultaneous determination of ¹H and ¹³C chemical shift differences through the analysis of highly resolved cross-peaks in spectral aliased pure shift (SAPS) HSQC spectra.

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Article information

DOI: https://doi.org/10.1039/C4CC04077E
Article type: Communication
Submitted: 28 May 2014
Accepted: 14 Jul 2014
First published: 14 Jul 2014

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Chem. Commun., 2014,50, 10214-10217

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Simultaneous ¹H and ¹³C NMR enantiodifferentiation from highly-resolved pure shift HSQC spectra

M. Pérez-Trujillo, L. Castañar, E. Monteagudo, L. T. Kuhn, P. Nolis, A. Virgili, R. T. Williamson and T. Parella, Chem. Commun., 2014, 50, 10214 DOI: 10.1039/C4CC04077E

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