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Issue 64, 2014
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Synthesis of 3,3-disubstituted indoline-2-thiones catalysed by an N-heterocyclic carbene

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Abstract

A catalytic method has been developed for construction of indoline-2-thiones containing an all-carbon quaternary centre at the C-3 position. Successive treatment of α,β-unsaturated aldehydes bearing an isothiocyanato moiety with an in situ generated N-heterocyclic carbene and an appropriate heteroatomic nucleophile provided the 3,3-disubstituted indoline derivatives in moderate to good yields.

Graphical abstract: Synthesis of 3,3-disubstituted indoline-2-thiones catalysed by an N-heterocyclic carbene

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Article information


Submitted
27 May 2014
Accepted
15 Jun 2014
First published
16 Jun 2014

Chem. Commun., 2014,50, 8871-8874
Article type
Communication
Author version available

Synthesis of 3,3-disubstituted indoline-2-thiones catalysed by an N-heterocyclic carbene

H. Ikota, T. Ishida, C. Tsukano and Y. Takemoto, Chem. Commun., 2014, 50, 8871
DOI: 10.1039/C4CC04047C

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