Issue 67, 2014

A general metal free approach to α-ketoamides via oxidative amidation–diketonization of terminal alkynes

Abstract

A novel catalytic system TMSOTf/I2/DMSO for the oxidative coupling of terminal alkynes with virtually any primary/secondary amine leading to α-ketoamides has been developed. The reaction possibly proceeds via iminium ion formation, wherein DMSO acts as a solvent as well as an oxidizing agent.

Graphical abstract: A general metal free approach to α-ketoamides via oxidative amidation–diketonization of terminal alkynes

Supplementary files

Article information

Article type
Communication
Submitted
19 May 2014
Accepted
11 Jun 2014
First published
12 Jun 2014

Chem. Commun., 2014,50, 9533-9535

Author version available

A general metal free approach to α-ketoamides via oxidative amidation–diketonization of terminal alkynes

R. Deshidi, M. Kumar, S. Devari and B. A. Shah, Chem. Commun., 2014, 50, 9533 DOI: 10.1039/C4CC03783A

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