An Affibody based dual imaging probe (PET and optical imaging) has been successfully developed. Dendrimer PAMAM G0 was used as a platform to assemble an NIRF dye, a metal chelator, and Affibody for dual modality imaging of ovarian cancer. Excellent tumor imaging quality was achieved in both modalities in the living tumor mice models.
Y. Wang, Z. Miao, G. Ren, Y. Xu and Z. Cheng, Chem. Commun., 2014, 50, 12832 DOI: 10.1039/C4CC03454F
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