Issue 68, 2014
From the journal:

Chemical Communications

Sensitive detection of microRNA by chronocoulometry and rolling circle amplification on a gold electrode†

Bo Yao,*a   Yichen Liu,b   Miyuki Tabata,c   Huangtianzhi Zhua  and  Yuji Miyahara*c  

* Corresponding authors

a Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310058, China
E-mail: yaobo08@zju.edu.cn
Fax: +86-571-88273572
Tel: +86-571-88273496

b Department of Chemistry, Lanzhou University, Lanzhou 730100, China

c Department of Bioelectronics, Tokyo Medical and Dental University, Tokyo 101-0062, Japan
E-mail: miyahara.bsr@tmd.ac.jp
Fax: +81-3-5280 8135
Tel: +81-3-5280 8095

Abstract

We developed a quantitative detection scheme for nucleic acids, combining solid-phase rolling circle amplification and chronocoulometry (RCA–CC). A gold electrode was directly formed on a polystyrene substrate as a cost-effective and flexible biosensor for sensitive detection of microRNA (mir-143) in blood samples.

Graphical abstract: Sensitive detection of microRNA by chronocoulometry and rolling circle amplification on a gold electrode

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Article information

DOI
https://doi.org/10.1039/C4CC03330B
Article type
Communication
Submitted
05 May 2014
Accepted
30 Jun 2014
First published
04 Jul 2014

Chem. Commun., 2014,50, 9704-9706

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Sensitive detection of microRNA by chronocoulometry and rolling circle amplification on a gold electrode

B. Yao, Y. Liu, M. Tabata, H. Zhu and Y. Miyahara, Chem. Commun., 2014, 50, 9704 DOI: 10.1039/C4CC03330B

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