Issue 62, 2014
From the journal:

Chemical Communications

Rational design of biotinylated probes: fluorescent turn-on detection of (strept)avidin and bioimaging in cancer cells†

Qian Sun,a   Junhong Qian,*a   Haiyu Tian,a   Liping Duanb  and  Weibing Zhang*a  

* Corresponding authors

a Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China
E-mail: junhongqian@ecust.edu.cn, weibingzhang@ecust.edu.cn

b National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China

Abstract

Two fluorescent probes SPS1 and SPS2 were designed by connecting biotin to an environment-sensitive coumarin fluorophore. Streptavidin and avidin induced dramatical fluorescence changes in both probes. SPS2 has potential in fluorescent imaging of biotin receptor-enriched tumor cells.

Graphical abstract: Rational design of biotinylated probes: fluorescent turn-on detection of (strept)avidin and bioimaging in cancer cells

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Article information

DOI
https://doi.org/10.1039/C4CC03315A
Article type
Communication
Submitted
04 May 2014
Accepted
10 Jun 2014
First published
11 Jun 2014

Chem. Commun., 2014,50, 8518-8521

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Rational design of biotinylated probes: fluorescent turn-on detection of (strept)avidin and bioimaging in cancer cells

Q. Sun, J. Qian, H. Tian, L. Duan and W. Zhang, Chem. Commun., 2014, 50, 8518 DOI: 10.1039/C4CC03315A

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